Title : Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells.

Pub. Date : 2021 Sep

PMID : 34271106






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 (2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -, OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity. 18alpha-glycyrrhetinic acid nitric oxide synthase 2 Homo sapiens
2 (2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -, OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity. 18alpha-glycyrrhetinic acid nitric oxide synthase 2 Homo sapiens
3 Taken together, GA could promote the productions of ROS and RNS via activating NADPH oxidases and iNOS, and decreasing GSH and GPX activity, subsequently aggravating lipid peroxidation and triggering ferroptosis in triple-negative breast cancer cells. 18alpha-glycyrrhetinic acid nitric oxide synthase 2 Homo sapiens