Title : Pharmacogenomics of Impaired Tyrosine Kinase Inhibitor Response: Lessons Learned From Chronic Myelogenous Leukemia.

Pub. Date : 2021

PMID : 34262462






1 Functional Relationships(s)
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1 By binding to the BCR-ABL1 kinase and inhibition of downstream target phosphorylation, TKIs, such as imatinib or nilotinib, can be used as single agents to treat CML patients resulting in 80 % 10-year survival rates. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens