Title : p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.

Pub. Date : 2021 Jul 13

PMID : 34244426






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro. Folic Acid tumor protein p53 Homo sapiens