Title : Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways.

Pub. Date : 2021 Aug

PMID : 34175886






3 Functional Relationships(s)
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1 Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
2 Mechanism study shows dexamethasone mediated transcriptional suppression of PD-L1 and IDO1 depends on the nuclear translocation of GR/STAT3 complex. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
3 These findings demonstrate dexamethasone can suppress immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways. Dexamethasone signal transducer and activator of transcription 3 Mus musculus