Title : Development of metabolic dysfunction in mice lacking chemerin.

Pub. Date : 2021 Sep 15

PMID : 34171420






6 Functional Relationships(s)
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1 During the following 4 weeks, chow- or high-fat diet maintained chemerin knockout mice showed elevated fasting glucose levels and glucose intolerance as well as insulin intolerance. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus
2 During the following 4 weeks, chow- or high-fat diet maintained chemerin knockout mice showed elevated fasting glucose levels and glucose intolerance as well as insulin intolerance. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus
3 Chemerin deficiency impaired adaptation to glucose and insulin challenge, leading to increased glucose levels. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus
4 Taken together, the results support the hypotheses that chemerin helps adapt glucose metabolism to changes in dietary fat and modulates glucose consumption in mice by activation of PGC-1alpha/GLUT4 axis. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus
5 Chemerin may play a significant role in elevation of glucose uptake and insulin sensitivity to promote glucose clearance. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus
6 Chemerin may play a significant role in elevation of glucose uptake and insulin sensitivity to promote glucose clearance. Glucose retinoic acid receptor responder (tazarotene induced) 2 Mus musculus