Title : Species Differences between Mouse and Human PPARĪ± in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARĪ± Agonist in Mice.

Pub. Date : 2021 Aug 30

PMID : 34081146






4 Functional Relationships(s)
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1 Activation of PPARalpha with GW7647 increased expression of known PPARalpha target genes in liver and was associated with hepatomegaly, increased hepatic cytotoxicity and necrosis, increased expression of hepatic MYC, and a high incidence of hepatocarcinogenesis in wild-type mice. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 Activation of PPARalpha with GW7647 increased expression of known PPARalpha target genes in liver and was associated with hepatomegaly, increased hepatic cytotoxicity and necrosis, increased expression of hepatic MYC, and a high incidence of hepatocarcinogenesis in wild-type mice. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
3 Results from these studies indicate that the mouse PPARalpha is required to mediate hepatocarcinogenesis induced by GW7647 in mice and that activation of the human PPARalpha with GW7647 in PPARA-humanized mice are diminished compared to wild-type mice. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
4 Results from these studies indicate that the mouse PPARalpha is required to mediate hepatocarcinogenesis induced by GW7647 in mice and that activation of the human PPARalpha with GW7647 in PPARA-humanized mice are diminished compared to wild-type mice. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus