Title : Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARĪ± Agonist in PPARA-Humanized Mice.

Pub. Date : 2021 Aug 30

PMID : 34081128






3 Functional Relationships(s)
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1 In wild-type mice, GW7647 caused hepatic expression of known PPARalpha target genes, hepatomegaly, hepatic MYC expression, hepatic cytotoxicity, and a high incidence of hepatocarcinogenesis. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 PPARA-humanized mice administered GW7647 also exhibited increased necrosis after five weeks of treatment. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
3 Results from these studies demonstrate that the mouse PPARalpha is required for hepatocarcinogenesis induced by GW7647 administered throughout adulthood. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus