Pub. Date : 2021 Aug 30
PMID : 34081128
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In wild-type mice, GW7647 caused hepatic expression of known PPARalpha target genes, hepatomegaly, hepatic MYC expression, hepatic cytotoxicity, and a high incidence of hepatocarcinogenesis. | GW 7647 | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | PPARA-humanized mice administered GW7647 also exhibited increased necrosis after five weeks of treatment. | GW 7647 | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Results from these studies demonstrate that the mouse PPARalpha is required for hepatocarcinogenesis induced by GW7647 administered throughout adulthood. | GW 7647 | peroxisome proliferator activated receptor alpha | Mus musculus |