Title : Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.

Pub. Date : 2021 May 26

PMID : 34073600






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Enzymatic activity of NNMT is important for the prevention of NAM-mediated inhibition of NAD+-consuming enzymes poly-adenosine -diphosphate (ADP), ribose polymerases (PARPs), and sirtuins (SIRTs). NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 Largely overlooked, in the context of cancer, is the inhibitory effect of 2-PY on PARP-1 activity, which abrogates NNMT"s positive effect on cellular NAD+ flux by stalling liberation of NAM and reducing NAD+ synthesis in the salvage pathway. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
3 Largely overlooked, in the context of cancer, is the inhibitory effect of 2-PY on PARP-1 activity, which abrogates NNMT"s positive effect on cellular NAD+ flux by stalling liberation of NAM and reducing NAD+ synthesis in the salvage pathway. NAD poly(ADP-ribose) polymerase 1 Homo sapiens