Title : Neuroregenerative Activity of the Dipeptide Mimetic of Brain-derived Neurotrophic Factor GSB-106 Under Experimental Ischemic Stroke.

Pub. Date : 2021

PMID : 34036924






2 Functional Relationships(s)
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1 BACKGROUND: A dimeric dipeptide mimetic of the BDNF loop 4, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106), which activates TrkB, PI3K/AKT, MAPK/ERK and PLC-gamma1 was created at the V.V. Dipeptides brain-derived neurotrophic factor Rattus norvegicus
2 CONCLUSIONS: Thus, the dimer dipeptide BDNF mimetic GSB-106 exhibits neuroregenerative properties at clinically relevant time window (24 h) in a model of ischemic stroke presumably due to stimulation of neurogenesis (and/or gliogenesis) and synaptogenesis. Dipeptides brain-derived neurotrophic factor Rattus norvegicus