Title : Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics.

Pub. Date : 2021 Oct 5

PMID : 34023736






1 Functional Relationships(s)
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1 Notably, when assayed for their biological cell responses mimicking SOCS1 activity, the internal cyclic PS5 analogues demonstrated able to inhibit JAK-mediated tyrosine phosphorylation of STAT1 and to reduce cytokine-induced proinflammatory gene expression, oxidative stress generation and cell migration. Tyrosine signal transducer and activator of transcription 1 Homo sapiens