Title : Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level.

Pub. Date : 2021 Jul 15

PMID : 34000577






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cur significantly inhibited the biosynthesis of spermine and spermidine by decreasing the expression of ornithine decarboxylase (ODC) and suppressed D-glutamine metabolism, which in turn decreased the anti-oxidative stress ability and P-gp transport activity of SW620/Ad300 cells, eventually reversed MDR. Spermidine ATP binding cassette subfamily B member 1 Homo sapiens