Title : Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD.

Pub. Date : 2021 Jul

PMID : 33871064






5 Functional Relationships(s)
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1 Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD. NAD CD38 antigen Mus musculus
2 Our previous study demonstrated that deletion of CD38, which consumes NAD+ , suppressed cuprizone-induced demyelination, neuroinflammation and glial activation. NAD CD38 antigen Mus musculus
3 However, it is still unknown whether CD38 directly affects neuroinflammation through regulating brain NAD+ level. NAD CD38 antigen Mus musculus
4 These results suggest that CD38-mediated neuroinflammation is linked to NAD+ consumption and that boosting NAD+ by CD38 inhibition and NR supplementation directly suppress neuroinflammation in the brain. NAD CD38 antigen Mus musculus
5 These results suggest that CD38-mediated neuroinflammation is linked to NAD+ consumption and that boosting NAD+ by CD38 inhibition and NR supplementation directly suppress neuroinflammation in the brain. NAD CD38 antigen Mus musculus