Title : Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages.

Pub. Date : 2021 Sep

PMID : 33846538






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. NAD sirtuin 1 Mus musculus
2 In conclusion, NR exerts anti-inflammatory and antioxidant properties by abrogating the inhibitory effects of ethanol on the SIRT1 pathway by increasing Sirt1 expression and its activator, NAD+. NAD sirtuin 1 Mus musculus
3 Also, SIRT1 activation and normalization of ethanol-induced changes in NAD+/NADH ratios by NR are likely crucial to counteract the changes in energy phenotypes of macrophages exposed to ethanol. NAD sirtuin 1 Mus musculus