Title : Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia.

Pub. Date : 2021 Jun

PMID : 33827113






1 Functional Relationships(s)
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1 One of the most effective molecules was Niclosamide, which markedly blunted calcium oscillations and membrane conductances in Spike-expressing cells by suppressing the activity of TMEM16F/Anoctamin6, a calcium-activated ion channel and scramblase responsible for phosphatidylserine exposure on the cell surface. Niclosamide surface glycoprotein Severe acute respiratory syndrome coronavirus 2