Title : Angiotensin II-Induced Cardiac Effects Are Modulated by Endocannabinoid-Mediated CB1 Receptor Activation.

Pub. Date : 2021 Mar 24

PMID : 33805075






6 Functional Relationships(s)
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1 Ang II activates the type-1 angiotensin receptor-Gq/11 signaling pathway resulting in the release of 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate angiotensinogen Rattus norvegicus
2 Ang II activates the type-1 angiotensin receptor-Gq/11 signaling pathway resulting in the release of 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate angiotensinogen Rattus norvegicus
3 Our findings indicate that Ang II-induced cardiac effects are modulated by simultaneous CB1R-activation, most likely due to 2-AG-release during Ang II signalling. glyceryl 2-arachidonate angiotensinogen Rattus norvegicus
4 Our findings indicate that Ang II-induced cardiac effects are modulated by simultaneous CB1R-activation, most likely due to 2-AG-release during Ang II signalling. glyceryl 2-arachidonate angiotensinogen Rattus norvegicus
5 In this combined effect, the response to 2-AG via cardiac CB1R may counteract the positive inotropic effect of Ang II, which may decrease metabolic demand and augment Ang II-induced coronary vasoconstriction. glyceryl 2-arachidonate angiotensinogen Rattus norvegicus
6 In this combined effect, the response to 2-AG via cardiac CB1R may counteract the positive inotropic effect of Ang II, which may decrease metabolic demand and augment Ang II-induced coronary vasoconstriction. glyceryl 2-arachidonate angiotensinogen Rattus norvegicus