Pub. Date : 2021 Jul
PMID : 33745117
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway. | h3s10 | protein phosphatase 1F (PP2C domain containing) | Mus musculus |
| 2 | Meanwhile, overexpression of PPM1F in the DG decreased total Bdnf exon-specific messenger RNA expression in the hippocampus with the decreased binding activity of phosphorylated H3S10 to its individual promoters in female mice. | h3s10 | protein phosphatase 1F (PP2C domain containing) | Mus musculus |
| 3 | These results may suggest that PPM1F regulates anxiety-related behaviors by modulating BDNF expression and H3S10 phosphorylation-mediated epigenetic modification, which may be served as potentially pathological genes associated with anxiety or other mental diseases. | h3s10 | protein phosphatase 1F (PP2C domain containing) | Mus musculus |