Title : HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.

Pub. Date : 2021 Mar 8

PMID : 33683197






1 Functional Relationships(s)
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1 This HPF1-mediated switch from polymerase to hydrolase has important implications for the PARP1-mediated response to DNA damage and raises interesting new questions about the role of intracellular ADPR and depletion of NAD+. NAD poly(ADP-ribose) polymerase 1 Homo sapiens