Title : Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling.

Pub. Date : 2021 Mar

PMID : 33603170






2 Functional Relationships(s)
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1 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Here we report that nicotine enhances ESCC cancer malignancy and tumor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and subsequently activating the JAK2/STAT3 signaling pathway. Nicotine signal transducer and activator of transcription 3 Homo sapiens