Title : Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner.

Pub. Date : 2021 Jan-Jun

PMID : 33482196






1 Functional Relationships(s)
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1 To dissect the direct effect of PARP1 on mtDNA from the secondary perturbation of metabolism, we report here biochemical studies that recapitulated Pol gamma PARylation observed in cells and showed that PARP1 regulates Pol gamma activity during DNA repair in a metabolic cofactor NAD+ (nicotinamide adenosine dinucleotide)-dependent manner. NAD poly(ADP-ribose) polymerase 1 Homo sapiens