Title : Multiple domain interfaces mediate SARM1 autoinhibition.

Pub. Date : 2021 Jan 26

PMID : 33468661






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In healthy neurons, SARM1 is autoinhibited and, upon injury autoinhibition is relieved, activating the SARM1 enzyme to deplete NAD+ and induce axon degeneration. NAD sterile alpha and TIR motif containing 1 Homo sapiens
2 In healthy neurons, SARM1 is autoinhibited and, upon injury autoinhibition is relieved, activating the SARM1 enzyme to deplete NAD+ and induce axon degeneration. NAD sterile alpha and TIR motif containing 1 Homo sapiens
3 Mutation of residues in full-length SARM1 within the region encompassed by the peptide led to loss of autoinhibition, rendering SARM1 constitutively active and inducing spontaneous NAD+ and axon loss. NAD sterile alpha and TIR motif containing 1 Homo sapiens