Title : High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme.

Pub. Date : 2020 Dec 22

PMID : 33353972






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The lead nanobody candidate, NIH-CoVnb-112, blocks SARS-CoV-2 spike pseudotyped lentivirus infection of HEK293 cells expressing human ACE2 with an EC50 of 0.3 microg/mL. nih-covnb-112 surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Furthermore, NIH-CoVnb-112 blocks interaction between ACE2 and several high affinity variant forms of the spike protein. nih-covnb-112 surface glycoprotein Severe acute respiratory syndrome coronavirus 2