Pub. Date : 2021 Feb
PMID : 33348310
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFkappa-B signaling pathway. | diacerein | toll-like receptor 4 | Rattus norvegicus |
| 2 | RESULTS: Diacerein pretreatment has the ability to restore the hepatic I/R damaging effect, proved by the reduction of serum liver enzymes, the decrease of the oxidative stress and hepatic inflammation via down-regulation of TLR4/ NFkappa-B signaling pathway together with the restoration of L-FABP level and improvement of the histopathological and immunohistochemical study findings in the hepatic tissue. | diacerein | toll-like receptor 4 | Rattus norvegicus |
| 3 | CONCLUSION: These results suggested the hepatoprotective effect of diacerein relies on its antioxidant and anti-inflammatory effects reducing TLR4/ NFkappa-B signaling pathway. | diacerein | toll-like receptor 4 | Rattus norvegicus |