Title : Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration.

Pub. Date : 2020 Dec 16

PMID : 33339104






3 Functional Relationships(s)
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1 It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by converting arachidonic acid into proinflammatory prostaglandin PGE2 and then producing other proinflammatory chemokines and cytokines. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by converting arachidonic acid into proinflammatory prostaglandin PGE2 and then producing other proinflammatory chemokines and cytokines. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 Our results reveal that during the inflammatory state, induced by intraplantar administration of carrageenan, the increase of PGE2 levels released in the paw exudates were associated with COX-2 nitration. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus