Title : Escin ameliorates the impairments of neurological function and blood brain barrier by inhibiting systemic inflammation in intracerebral hemorrhagic mice.

Pub. Date : 2021 Mar

PMID : 33309746






3 Functional Relationships(s)
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1 Escin ameliorated the increasing levels of RhoA, ROCK1, nuclear NF-kappaB and the decreasing expression of IkappaBalpha, cytosolic NF-kappaB, occludin, claudin-5 in the ICH group. Escin ras homolog family member A Mus musculus
2 IL-1beta administration blocked not only escin-mediated increases of IkappaBalpha, cytosolic NF-kappaB, occludin, and claudin-5, but also escin-caused decreases of RhoA, ROCK1, and nuclear NF-kappaB. Escin ras homolog family member A Mus musculus
3 The results indicate that escin improves neurological outcomes and the BBB function in ICH mice, which is associated with attenuating ICH-induced peripheral system inflammation, and therefore, inhibiting IL-1beta/RhoA/NF-kappaB signaling pathway in BBB, at least in part. Escin ras homolog family member A Mus musculus