Pub. Date : 2021 Jun
PMID : 33244652
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 2 | RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS). | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 3 | RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS). | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 4 | Interestingly, although both isomers of RSV bind to TyrRS, only the cis-isomer evokes a unique structural change at the active site to promote its interaction with poly-ADP-ribose polymerase 1 (PARP1), a major determinant of cellular NAD+-dependent stress response. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 5 | However, retention of trans-RSV in the active site of TyrRS mimics its tyrosine-bound conformation that inhibits the auto-poly-ADP-ribos(PAR)ylation of PARP1. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 6 | Therefore, we proposed that cis-RSV-induced TyrRS-regulated auto-PARylation of PARP1 would contribute, at least in part, to the reported health benefits of RSV through the induction of protective stress response. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 7 | Therefore, we proposed that cis-RSV-induced TyrRS-regulated auto-PARylation of PARP1 would contribute, at least in part, to the reported health benefits of RSV through the induction of protective stress response. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 8 | This observation suggested that trans-RSV would inhibit TyrRS/PARP1-mediated protective stress response and would instead elicit an opposite effect compared to cis-RSV. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 9 | Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 10 | Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |
| 11 | Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms. | Resveratrol | tyrosyl-tRNA synthetase 1 | Homo sapiens |