Title : Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPAR╬│) activation following binding to ╬▒2 adrenoceptors.

Pub. Date : 2021 Feb 5

PMID : 33220278






2 Functional Relationships(s)
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1 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandins peroxisome proliferator activated receptor gamma Mus musculus
2 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandins peroxisome proliferator activated receptor gamma Mus musculus