Title : Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.

Pub. Date : 2020 Oct 27

PMID : 33080008






1 Functional Relationships(s)
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Protein Name
Organism
1 The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in clinical trials of acute myeloid leukemia (AML) and certain solid cancers. birinapant diablo, IAP-binding mitochondrial protein Mus musculus