Pub. Date : 2021 Jan
PMID : 33077484
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results suggest that the surge of ACSL4 levels by targeting AR signaling increases fatty acyl-CoAs biosynthesis and protein myristoylation, indicating the opposite yet complementary or Yin-Yang regulation of ACSL3 and 4 levels in sustaining fatty acid metabolism when targeting androgen-AR signaling. | Fatty Acids | acyl-CoA synthetase long chain family member 3 | Homo sapiens |
| 2 | Implications: Androgen receptor coordinately regulates the expression of ACSL3 and ACSL4, such that AR pathway-independent prostate tumors become dependent on ACSL4-mediated fatty acid metabolism. | Fatty Acids | acyl-CoA synthetase long chain family member 3 | Homo sapiens |