Title : Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.

Pub. Date : 2021 Jan

PMID : 33077484






2 Functional Relationships(s)
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1 Our results suggest that the surge of ACSL4 levels by targeting AR signaling increases fatty acyl-CoAs biosynthesis and protein myristoylation, indicating the opposite yet complementary or Yin-Yang regulation of ACSL3 and 4 levels in sustaining fatty acid metabolism when targeting androgen-AR signaling. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens
2 Implications: Androgen receptor coordinately regulates the expression of ACSL3 and ACSL4, such that AR pathway-independent prostate tumors become dependent on ACSL4-mediated fatty acid metabolism. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens