Title : Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.

Pub. Date : 2020 Aug 28

PMID : 32859916






2 Functional Relationships(s)
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1 Knockout of Tmem16a or inhibition of TMEM16A in vivo by the FDA-approved drugs niclosamide and benzbromarone, as well as the TMEM16A-specific inhibitor Ani9 largely reduced cyst enlargement and abnormal cyst cell proliferation. Niclosamide anoctamin 1, calcium activated chloride channel Mus musculus
2 Knockout of Tmem16a or inhibition of TMEM16A in vivo by the FDA-approved drugs niclosamide and benzbromarone, as well as the TMEM16A-specific inhibitor Ani9 largely reduced cyst enlargement and abnormal cyst cell proliferation. Niclosamide anoctamin 1, calcium activated chloride channel Mus musculus