Title : [On the mechanism of action of valproid acid].

Pub. Date : 1977

PMID : 328017






3 Functional Relationships(s)
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1 It was shown that the elevation of GABA by DPA was accompanied by an activation of GAD. Valproic Acid glutamate-ammonia ligase (glutamine synthetase) Mus musculus
2 DPA proved able to antagonize the biochemical alterations induced by convulsant doses of isoniazid, i.e., decreases in the level of GABA and the activity of GAD. Valproic Acid glutamate-ammonia ligase (glutamine synthetase) Mus musculus
3 These results point to a role of the transmitter pool of GABA regulated by GAD in the anticonvulsant effect of DPA. Valproic Acid glutamate-ammonia ligase (glutamine synthetase) Mus musculus