Title : Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.

Pub. Date : 2020 Oct 1

PMID : 32755678






2 Functional Relationships(s)
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1 Previously, we reported S-Trityl-L-Cysteine (STLC)-ornamented dimethylaminopyridine chemical entity named STC4 with a significant SIRT2 inhibitory capacity; this was separate from the conventional application of STLC scaffold as a kinesin-5 inhibitor. 3-tritylthio-L-alanine sirtuin 2 Homo sapiens
2 Previously, we reported S-Trityl-L-Cysteine (STLC)-ornamented dimethylaminopyridine chemical entity named STC4 with a significant SIRT2 inhibitory capacity; this was separate from the conventional application of STLC scaffold as a kinesin-5 inhibitor. 3-tritylthio-L-alanine sirtuin 2 Homo sapiens