Title : Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Pub. Date : 2020 Sep

PMID : 32719536






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1 Here we report a new level of regulation wherein LCFA-CoA esters per se allosterically activate AMP-activated protein kinase (AMPK) beta1-containing isoforms to increase fatty acid oxidation through phosphorylation of acetyl-CoA carboxylase. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens