Title : Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.

Pub. Date : 2020 Jul 1

PMID : 32695416






1 Functional Relationships(s)
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1 The structure reveals how the DHTKD1 active site is modelled upon the well characterized homologue 2-oxoglutarate (2OG) de-hydrogenase but engineered specifically to accommodate its preference for the longer substrate of 2OA over 2OG. Ketoglutaric Acids dehydrogenase E1 and transketolase domain containing 1 Homo sapiens