Title : Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.

Pub. Date : 2020

PMID : 32655764






2 Functional Relationships(s)
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1 Interestingly, we highlight that PI3K/AKT inhibitor (LY294002) markedly increased the expression of Nrf2 antioxidant pathway, PPARalpha, and downregulated SREBP-1c in FFA-stimulated HepG2 cells. Fatty Acids, Nonesterified sterol regulatory element binding transcription factor 1 Homo sapiens
2 For these reasons, we found that the deletion of Nrf2 could lose the protective effects of GPS on the Nrf2 antioxidant pathway and PPARalpha activation and SREBP-1c inactivation in FFA-stimulated HepG2 cells and Ty-treated mice. Fatty Acids, Nonesterified sterol regulatory element binding transcription factor 1 Homo sapiens