Title : The English (H6R) Mutation of the Alzheimer's Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation.

Pub. Date : 2020 Jun 25

PMID : 32630528






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The coordination of zinc ions by histidine residues of amyloid-beta peptide (Abeta) plays a critical role in the zinc-induced Abeta aggregation implicated in Alzheimer"s disease (AD) pathogenesis. Histidine amyloid beta precursor protein Homo sapiens
2 The histidine to arginine substitution at position 6 of the Abeta sequence (H6R, English mutation) leads to an early onset of AD. Histidine amyloid beta precursor protein Homo sapiens