Pub. Date : 2020 Jul 17
PMID : 32568522
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL. | nimbolide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. | nimbolide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. | nimbolide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. | nimbolide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. | nimbolide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |