Title : Manganese exposure caused reproductive toxicity of male mice involving activation of GnRH secretion in the hypothalamus by prostaglandin E2 receptors EP1 and EP2.

Pub. Date : 2020 Sep 15

PMID : 32502905






5 Functional Relationships(s)
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1 Manganese exposure caused reproductive toxicity of male mice involving activation of GnRH secretion in the hypothalamus by prostaglandin E2 receptors EP1 and EP2. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 Astrocytes can indirectly regulate the secretion of GnRH by binding paracrine prostaglandin E2 (PGE2) specifically to the EP1 and EP2 receptors on GnRH neurons. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
3 Astrocytes can indirectly regulate the secretion of GnRH by binding paracrine prostaglandin E2 (PGE2) specifically to the EP1 and EP2 receptors on GnRH neurons. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
4 Our data demonstrate that antagonizing the EP1 and EP2 receptors of PGE2 can restore abnormal levels of GnRH caused by Mn exposure. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
5 These findings suggest that EP1 and EP2, the receptors of PGE2, may be the key to abnormal GnRH secretion caused by Mn exposure. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus