Title : Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex-associated cystic kidney disease.

Pub. Date : 2020 Jul 9

PMID : 32484794






2 Functional Relationships(s)
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1 Injection of rapamycin to pregnant mice inhibited the mTOR pathway and tubular cell proliferation in kidneys of TSC1 null offspring. Sirolimus TSC complex subunit 1 Mus musculus
2 Gene expression analysis of proximal tubule cells, identified sets of genes and pathways that were modified secondary to TSC1 deletion and rescued by rapamycin administration during nephrogenesis. Sirolimus TSC complex subunit 1 Mus musculus