Title : IL-1β Enhances the Antiviral Effect of IFN-α on HCV Replication by Negatively Modulating ERK2 Activation.

Pub. Date : 2020 Jul 10

PMID : 32420725






2 Functional Relationships(s)
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1 Our data indicated that IL-1beta alone does not inhibit HCV replication, yet when in combination with IFN-alpha, it can boost anti-HCV activity of IFN-alpha, which is mediated by augmented STAT1 tyrosine 701 phosphorylation. Tyrosine signal transducer and activator of transcription 1 Homo sapiens
2 Our study found that IL-1beta negatively affects ERK2 phosphorylation, which suggests that IL-1beta mediated STAT1 tyrosine 701 phosphorylation employed kinase machinery of ERK2 other than JNK or P38 kinase. Tyrosine signal transducer and activator of transcription 1 Homo sapiens