Title : Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation.

Pub. Date : 2020 Jun 4

PMID : 32343675






4 Functional Relationships(s)
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Protein Name
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1 AM expression of cholesterol-25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds that of macrophages in other tissues, but no role for CH25H has been defined in lung biology. 25-hydroxycholesterol cholesterol 25-hydroxylase Mus musculus
2 AM expression of cholesterol-25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds that of macrophages in other tissues, but no role for CH25H has been defined in lung biology. 25-hydroxycholesterol cholesterol 25-hydroxylase Mus musculus
3 As 25HC is an agonist for the anti-inflammatory nuclear receptor, Liver X Receptor (LXR), we speculated that CH25H might regulate inflammatory homeostasis in the lung. 25-hydroxycholesterol cholesterol 25-hydroxylase Mus musculus
4 Ch25h-/- mice fail to induce 25HC and LXR target genes in the lung after LPS inhalation and exhibit delayed resolution of airway neutrophilia which can be rescued by systemic treatment with either 25HC or synthetic LXR agonists. 25-hydroxycholesterol cholesterol 25-hydroxylase Mus musculus