Title : Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer.

Pub. Date : 2020 Apr 20

PMID : 32312965






2 Functional Relationships(s)
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1 We identified that binding of COL11A1 to its receptors, alpha1beta1 integrin and discoidin domain receptor 2 (DDR2), activates Src-Akt-AMPK signaling to increase the expression of both fatty acid synthesis and oxidation enzymes, although DDR2 seems to be the predominant receptor. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
2 Taken together, our results suggest that COL11A1 upregulates fatty acid metabolism in ovarian cancer cells in a DDR2-Src-Akt-AMPK dependent manner. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens