Title : Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with a disorder of l-lysine metabolism.

Pub. Date : 2020 Jun 5

PMID : 32303640






1 Functional Relationships(s)
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1 A multipronged systematic analysis of the reaction rates in the OADHc pathway, supplemented with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185G A DHTKD1 mutation affects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates. 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazine dehydrogenase E1 and transketolase domain containing 1 Homo sapiens