Title : Aggregation and de-aggregation of gold nanoparticles induced by polyionic drugs: spectrofluorimetric determination of picogram amounts of protamine and heparin drugs in the presence of 1000-fold concentration of major interferences.

Pub. Date : 2013 Nov 7

PMID : 32261185






3 Functional Relationships(s)
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1 Interestingly, on addition of 0.5 mug mL-1 heparin into aggregated FA-AuNPs, the absorption maximum attained a blue shift and the wine red color reverted back. Heparin L1 cell adhesion molecule Mus musculus
2 In contrast, addition of 65 pg mL-1 heparin into aggregated FA-AuNPs enhanced their emission intensity at 780 nm in the presence of 1040-fold higher concentrations of the above-mentioned interferences. Heparin L1 cell adhesion molecule Mus musculus
3 The lowest detection limits were found to be 4.8 x 10-15 g mL-1 for protamine and 12.6 x 10-15 g mL-1 for heparin (S/N = 3). Heparin L1 cell adhesion molecule Mus musculus