Title : A heretical view: rather than a solely placental protective function, placental 11β hydroxysteroid dehydrogenase 2 also provides substrate for fetal peripheral cortisol synthesis in obese pregnant ewes.

Pub. Date : 2021 Feb

PMID : 32151296






1 Functional Relationships(s)
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1 We hypothesized that OB pregnancies would show increased placental 11beta hydroxysteroid dehydrogenase 2 (11beta-HSD2) that converts maternal cortisol to fetal cortisone as it crosses the placenta and increased 11beta-HSD system components responsible for peripheral tissue cortisol production, providing a mechanism for ACTH-independent increase in circulating fetal cortisol. Cortisone proopiomelanocortin Homo sapiens