Title : Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.

Pub. Date : 2020 Apr 30

PMID : 32093891






6 Functional Relationships(s)
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1 We focused on oleic acid, an omega-9 monounsaturated fatty acid, as a factor that activates PPARdelta. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus
2 In this study, we examined the effects of oleic acid on the muscle fiber type of C2C12 myotubes and its relationship with PPARdelta. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus
3 To confirm the relationship between PPARdelta activation and oleic acid-induced MyHC1 increase, we examined the effects of oleic acid in PPARdelta knockdown C2C12 myoblasts. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus
4 To confirm the relationship between PPARdelta activation and oleic acid-induced MyHC1 increase, we examined the effects of oleic acid in PPARdelta knockdown C2C12 myoblasts. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus
5 We found that oleic acid supplementation increased the mRNA expression of MyHC1 in PPARdelta-knockdown C2C12 cells. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus
6 Our data suggest that oleic acid increases type 1 fiber levels in C2C12 myotubes in a PPARdelta-independent manner. Oleic Acid peroxisome proliferator activator receptor delta Mus musculus