Pub. Date : 2020 Jul
PMID : 32087251
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | SARM1 is an injury-activated NAD+ cleavage enzyme, and this NADase activity is required for the pro-degenerative function of SARM1. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
2 | SARM1 is an injury-activated NAD+ cleavage enzyme, and this NADase activity is required for the pro-degenerative function of SARM1. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
3 | At present, SARM1 function is assayed by either analysis of axonal loss, which is far downstream of SARM1 enzymatic activity, or via NAD+ levels, which are regulated by many competing pathways. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
4 | Here we explored the utility of measuring cADPR, a product of SARM1-dependent cleavage of NAD+, as an in cell and in vivo biomarker of SARM1 enzymatic activity. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |