Title : cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.

Pub. Date : 2020 Jul

PMID : 32087251






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SARM1 is an injury-activated NAD+ cleavage enzyme, and this NADase activity is required for the pro-degenerative function of SARM1. NAD sterile alpha and TIR motif containing 1 Homo sapiens
2 SARM1 is an injury-activated NAD+ cleavage enzyme, and this NADase activity is required for the pro-degenerative function of SARM1. NAD sterile alpha and TIR motif containing 1 Homo sapiens
3 At present, SARM1 function is assayed by either analysis of axonal loss, which is far downstream of SARM1 enzymatic activity, or via NAD+ levels, which are regulated by many competing pathways. NAD sterile alpha and TIR motif containing 1 Homo sapiens
4 Here we explored the utility of measuring cADPR, a product of SARM1-dependent cleavage of NAD+, as an in cell and in vivo biomarker of SARM1 enzymatic activity. NAD sterile alpha and TIR motif containing 1 Homo sapiens