Title : Bile acid transporter mediated STC/Soluplus self-assembled hybrid nanoparticles for enhancing the oral drug bioavailability.

Pub. Date : 2020 Apr 15

PMID : 32035254






3 Functional Relationships(s)
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1 The permeability of FLDP loaded STC/Soluplus SHNPs was STC dependent in the ileum, which was inhibited by the higher concentrations of STC and the inhibitor of apical sodium-dependent bile acid transporter (ASBT). polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer solute carrier family 10 member 2 Homo sapiens
2 The permeability of FLDP loaded STC/Soluplus SHNPs was STC dependent in the ileum, which was inhibited by the higher concentrations of STC and the inhibitor of apical sodium-dependent bile acid transporter (ASBT). polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer solute carrier family 10 member 2 Homo sapiens
3 In conclusion, STC/Soluplus SHNPs via ASBT are a potential strategy for enhancing the oral bioavailability of poorly water-soluble drugs. polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer solute carrier family 10 member 2 Homo sapiens