Title : HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.

Pub. Date : 2020 Mar

PMID : 32028527






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In response to DNA damage and NAD+ binding site occupancy, the HPF1-PARP1/2 interaction is enhanced via allosteric networks operating within PARP1/2, providing an additional level of regulation in DNA repair induction. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 In response to DNA damage and NAD+ binding site occupancy, the HPF1-PARP1/2 interaction is enhanced via allosteric networks operating within PARP1/2, providing an additional level of regulation in DNA repair induction. NAD poly(ADP-ribose) polymerase 1 Homo sapiens