Pub. Date : 2020 Jan 21
PMID : 31964975
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 2 | In this study, by combining in silico analysis and sgRNA library based drug resistance screening assay, we identified SENP2 (Sentrin/SUMO-specific proteases-2) as a bortezomib sensitive gene and found its expression highly downregulated in bortezomib resistant multiple myeloma patient"s samples. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 3 | In this study, by combining in silico analysis and sgRNA library based drug resistance screening assay, we identified SENP2 (Sentrin/SUMO-specific proteases-2) as a bortezomib sensitive gene and found its expression highly downregulated in bortezomib resistant multiple myeloma patient"s samples. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 4 | Furthermore, down regulation of SENP2 in multiple myeloma cell line RPMI8226 alleviated bortezomib induced cell proliferation inhibition and apoptosis, whereas, overexpression of SENP2 sensitized these cells to bortezomib treatment. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 5 | Furthermore, down regulation of SENP2 in multiple myeloma cell line RPMI8226 alleviated bortezomib induced cell proliferation inhibition and apoptosis, whereas, overexpression of SENP2 sensitized these cells to bortezomib treatment. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 6 | Furthermore, down regulation of SENP2 in multiple myeloma cell line RPMI8226 alleviated bortezomib induced cell proliferation inhibition and apoptosis, whereas, overexpression of SENP2 sensitized these cells to bortezomib treatment. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |
| 7 | Taken together, we report that silencing of SENP2 and consequent activation of NF-kappaB through the modulation of IkappaBalpha sumoylation as a novel mechanism inducing bortezomib resistance in multiple myeloma. | bortezomib | SUMO specific peptidase 2 | Homo sapiens |