Title : Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via α7nAChR-mediated JAK2/STAT3 signaling pathway.

Pub. Date : 2020 Feb 15

PMID : 31953160






4 Functional Relationships(s)
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1 Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine signal transducer and activator of transcription 3 Homo sapiens
4 SIGNIFICANCE: Our finding suggests that nicotine can promote activation of human pancreatic stellate cells (hPSCs) through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway, providing a new insight into the mechanisms by which nicotine affects pancreatic fibrosis. Nicotine signal transducer and activator of transcription 3 Homo sapiens